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. 2023 May 2;11:1182404. doi: 10.3389/fchem.2023.1182404

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Copyright © 2023 Lim, Yagnik, Henkel, Frost, Bien and Rothschild.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mass spectrometry imaging of glycans in an FFPE breast cancer specimen using PC-MT lectin probes. (A) 4-Plex PC-MT lectin panel used and their carbohydrate selectivity. (B) MALDI-MS image of the four PC-MT lectins on the FFPE breast cancer specimen (see color key in image). To show specificity of lectin binding (of WGA in this case), the mixture of PC-MT lectin probes was spiked and pre-incubated with the soluble sugar N,N′,N′′-Triacetyl-chitotriose (TCT) which specifically binds WGA. (C) WGA image alone with the TCT blockade (left) and without the TCT blockade on an adjacent (serial) tissue section on the same slide (right).