Examples of WM and GM longitudinal magnetizations (Mz) evolution in a repetition period (TR) for the EDGE (A) and EDGE-MP2RAGE (B) sequences. With EDGE contrast (A), the center of the data-acquisition window, which coincides with the k-space center (ie, k = 0), is placed when WM and GM have comparable signal intensity but opposite polarity. With EDGE-MP2RAGE (B), the first acquisition (ie, INV 1) is designed to provide the EDGE contrast. A.U. indicates arbitrary unit.