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. 2023 Apr 4;66(4):1208–1239. doi: 10.1044/2022_JSLHR-22-00510
DS TD
Prepubertal /i/ /u/ /æ/ /ɑ/ /i/ /u/ /æ/ /ɑ/
M (SD) M (SD) M (SD) M (SD) M (SD) M (SD) M (SD) M (SD)
f o F 287.93 (28.56) 276.24 (35.63) 270.90 (27.84) 271.80 (23.89) 250.79 (24.97) 235.83 (24.85) 239.19 (14.72) 237.15 (19.28)
M 274.56 (37.34) 268.42 (36.47) 260.85 (35.26) 254.43 (41.46) 250.12 (37.34) 234.12 (32.11) 238.09 (29.54) 239.17 (34.80)
F1 F 485.95 (83.90) 520.49 (83.07) 1022.35 (167.50) 1089.88 (132.25) 405.93 (55.02) 454.28 (69.30) 1008.79 (155.80) 1210.46 (99.36)
M 472.90 (83.48) 469.55 (64.63) 992.13 (130.02) 1096.71 (147.22) 397.94 (45.94) 430.75 (54.53) 957.75 (131.44) 1146.54 (153.17)
F2 F 3316.06 (149.82) 1405.14 (182.10) 2437.32 (201.91) 2029.65 (123.60) 3487.59 (230.43) 1321.07 (119.02) 2620.19 (214.07) 1839.58 (198.73)
M 3130.43 (209.52) 1479.13 (244.15) 2246.85 (157.19) 1972.88 (193.12) 3350.12 (182.74) 1201.77 (175.32) 2521.97 (219.92) 1732.86 (198.15)
F3 F 3992.45 (199.55) 3558.38 (161.73) 3857.95 (275.91) 3637.23 (415.72) 4192.12 (331.45) 3614.07 (305.70) 3713.52 (248.34) 3509.67 (294.54)
M 3889.25 (223.46) 3620.98 (215.70) 3755.86 (267.36) 3667.42 (417.75) 4017.05 (280.24) 3456.09 (287.40) 3625.48 (261.25) 3366.96 (288.50)
F4 F 5176.23 (218.65) 4829.42 (198.03) 4970.61 (338.40) 4728.43 (194.09) 5184.88 (378.18) 4799.06 (426.00) 4970.57 (371.90) 4625.33 (329.53)
M 4962.83 (316.67) 4664.98 (265.51) 4837.16 (242.42) 4662.43 (300.81) 5032.13 (351.49) 4616.61 (309.56) 4730.68 (311.03) 4459.43 (295.38)
Peripubertal /i/ /u/ /æ/ /ɑ/ /i/ /u/ /æ/ /ɑ/
M (SD) M (SD) M (SD) M (SD) M (SD) M (SD) M (SD) M (SD)
f o F 251.51 (35.55) 236.37 (30.47) 237.18 (37.29) 235.65 (27.07) 230.37 (9.91) 216.04 (15.49) 222.92 (15.92) 216.83 (13.99)
M 243.84 (27.04) 223.15 (29.51) 213.17 (36.98) 227.96 (25.75) 231.23 (21.49) 222.56 (25.99) 222.42 (22.58) 222.44 (21.06)
F1 F 435.50 (43.97) 438.06 (75.50) 944.14 (123.49) 1076.34 (119.52) 398.75 (29.71) 432.72 (35.65) 987.75 (111.87) 1152.32 (104.44)
M 419.90 (66.61) 391.59 (91.23) 964.96 (180.42) 1024.62 (125.30) 378.06 (45.95) 399.56 (35.38) 919.70 (113.55) 1028.45 (83.30)
F2 F 3149.05 (142.01) 1401.36 (204.56) 2326.52 (192.00) 1870.90 (156.03) 3254.26 (216.86) 1274.06 (108.88) 2336.23 (152.32) 1712.71 (163.50)
M 2967.81 (223.13) 1397.64 (326.52) 2241.13 (223.22) 1698.38 (197.36) 3068.71 (193.80) 1147.44 (144.59) 2158.60 (151.46) 1566.53 (84.53)
F3 F 3712.00 (170.31) 3311.01 (215.04) 3484.32 (132.29) 3390.04 (253.76) 3912.62 (295.75) 3266.26 (180.27) 3381.77 (211.40) 3269.11 (181.60)
M 3689.79 (203.57) 3330.40 (267.26) 3548.51 (313.82) 3349.91 (343.30) 3640.00 (204.68) 3137.21 (172.94) 3232.56 (143.72) 3088.67 (275.04)
F4 F 4757.37 (206.29) 4467.18 (170.74) 4478.29 (234.25) 4327.69 (259.92) 4823.37 (280.44) 4483.78 (321.08) 4575.84 (296.19) 4371.13 (206.11)
M 4766.75 (359.39) 4362.18 (296.89) 4636.58 (335.73) 4375.14 (266.94) 4578.56 (212.15) 4339.34 (209.38) 4323.60 (208.84) 4199.44 (277.11)
Pubertal /i/ /u/ /æ/ /ɑ/ /i/ /u/ /æ/ /ɑ/
M (SD) M (SD) M (SD) M (SD) M (SD) M (SD) M (SD) M (SD)
f o F 228.27 (33.44) 220.86 (26.15) 220.88 (20.57) 218.82 (26.47) 222.05 (23.09) 220.76 (22.85) 215.68 (24.05) 214.96 (24.43)
M 177.93 (56.47) 170.73 (48.98) 169.22 (53.05) 166.86 (52.36) 195.40 (47.45) 187.62 (46.96) 187.90 (45.49) 190.34 (49.48)
F1 F 405.64 (51.86) 423.68 (69.28) 832.98 (155.36) 910.61 (111.10) 376.31 (45.18) 401.42 (55.97) 924.55 (89.62) 1041.24 (82.76)
M 370.19 (41.42) 379.71 (46.32) 771.66 (127.07) 841.53 (139.21) 347.36 (54.54) 359.34 (49.67) 826.23 (122.26) 940.15 (126.49)
F2 F 2778.63 (333.16) 1304.01 (180.04) 2090.43 (219.79) 1585.17 (137.87) 2923.11 (199.06) 1229.12 (148.79) 2115.68 (161.41) 1609.45 (152.05)
M 2626.56 (365.00) 1227.76 (185.93) 2004.23 (334.73) 1512.78 (252.30) 2757.28 (255.00) 1088.72 (123.78) 2008.89 (192.32) 1465.67 (144.85)
F3 F 3371.61 (373.36) 2832.64 (255.23) 2988.27 (244.36) 2793.27 (315.64) 3527.65 (253.43) 2957.52 (233.93) 3121.02 (178.36) 3056.55 (232.33)
M 3232.55 (399.37) 2881.10 (525.09) 3101.08 (417.70) 2858.14 (417.97) 3369.41 (285.38) 2778.28 (282.33) 2946.10 (246.93) 2800.59 (214.19)
F4 F 4432.69 (467.69) 3993.02 (400.55) 4104.04 (266.82) 3989.14 (245.82) 4414.59 (289.80) 4114.01 (336.77) 4267.26 (232.83) 4122.61 (222.37)
M 4208.64 (434.04) 3937.04 (444.62) 4133.44 (478.17) 3984.66 (369.91) 4262.56 (331.07) 3987.10 (378.19) 4070.87 (268.38) 3960.70 (292.95)
Postpubertal /i/ /u/ /æ/ /ɑ/ /i/ /u/ /æ/ /ɑ/
M (SD) M (SD) M (SD) M (SD) M (SD) M (SD) M (SD) M (SD)
f o F 215.24 (22.99) 211.52 (25.99) 213.44 (31.57) 207.34 (25.13) 213.30 (21.26) 215.62 (19.31) 211.79 (20.51) 207.83 (21.91)
M 143.48 (28.50) 137.37 (27.53) 134.01 (25.49) 136.67 (28.90) 105.21 (20.48) 105.20 (21.70) 101.25 (21.16) 102.18 (21.60)
F1 F 380.85 (27.23) 414.32 (48.87) 829.75 (144.55) 973.80 (114.62) 356.94 (32.62) 380.04 (41.96) 871.66 (64.43) 972.37 (69.95)
M 305.44 (50.06) 313.21 (49.67) 687.57 (111.99) 764.89 (125.43) 274.03 (27.25) 316.48 (34.86) 684.39 (57.01) 767.26 (65.23)
F2 F 2669.74 (275.34) 1310.36 (216.46) 2020.82 (157.71) 1601.86 (187.38) 2789.25 (166.50) 1193.66 (165.54) 2011.11 (128.02) 1502.76 (95.92)
M 2352.41 (257.86) 1064.46 (124.58) 1791.79 (205.65) 1378.73 (168.28) 2289.90 (189.31) 1021.64 (120.91) 1701.83 (122.30) 1239.86 (89.04)
F3 F 3265.62 (332.39) 2748.14 (273.87) 2957.78 (268.63) 2715.60 (285.79) 3360.65 (220.00) 2749.70 (138.50) 2928.28 (157.47) 2829.59 (159.49)
M 2945.00 (254.08) 2400.98 (211.76) 2611.45 (218.46) 2450.21 (247.59) 2959.85 (218.42) 2368.70 (158.83) 2564.89 (129.01) 2570.92 (165.52)
F4 F 4213.58 (414.89) 3735.10 (282.56) 4034.78 (286.59) 3950.36 (255.33) 4242.77 (265.62) 3948.86 (262.22) 4159.10 (218.64) 3966.19 (189.51)
M 3799.80 (309.09) 3473.87 (267.33) 3738.24 (215.54) 3658.98 (241.96) 3566.47 (239.61) 3355.57 (243.43) 3635.50 (240.78) 3575.67 (186.34)
Adults /i/ /u/ /æ/ /ɑ/ /i/ /u/ /æ/ /ɑ/
M (SD) M (SD) M (SD) M (SD) M (SD) M (SD) M (SD) M (SD)
f o F 211.14 (28.02) 198.50 (23.50) 200.25 (18.16) 197.13 (21.95) 193.07 (28.35) 192.34 (28.99) 181.92 (29.61) 180.39 (28.68)
M 146.15 (25.67) 143.15 (22.75) 137.66 (24.55) 135.63 (24.63) 114.55 (18.87) 115.50 (19.14) 109.69 (19.07) 108.27 (17.8)
F1 F 371.12 (44.71) 398.96 (42.62) 748.19 (115.42) 962.06 (109.69) 340.84 (40.13) 352.21 (39.92) 800.14 (101.25) 977.07 (98.87)
M 311.16 (46.48) 321.28 (49.07) 679.56 (78.42) 806.30 (113.77) 278.85 (23.96) 310.02 (30.93) 637.54 (52.57) 773.03 (70.34)
F2 F 2654.71 (258.10) 1151.93 (169.08) 2065.27 (145.91) 1553.02 (127.92) 2770.05 (175.27) 1056.56 (123.00) 2117.72 (173.02) 1484.25 (115.02)
M 2442.35 (714.49) 1065.66 (153.21) 1825.75 (144.50) 1385.67 (174.04) 2261.91 (156.74) 940.95 (109.74) 1752.73 (125.59) 1291.83 (77.60)
F3 F 3269.53 (266.28) 2728.45 (261.52) 2961.93 (212.98) 2765.57 (268.86) 3350.72 (202.87) 2751.47 (173.11) 2943.98 (158.22) 2830.57 (183.48)
M 2895.11 (221.62) 2473.85 (183.78) 2606.12 (134.56) 2512.67 (168.85) 2902.03 (157.88) 2325.81 (149.81) 2513.65 (137.88) 2546.28 (143.69)
F4 F 4250.44 (339.06) 3853.15 (344.49) 4078.75 (268.14) 3938.86 (283.27) 4191.41 (253.38) 3869.40 (251.56) 4107.42 (258.44) 3908.52 (281.99)
M 3734.37 (252.31) 3418.86 (223.11) 3621.09 (270.32) 3582.63 (213.72) 3583.99 (211.61) 3266.38 (215.82) 3515.15 (232.54) 3516.50 (194.33)

Note. DS = Down syndrome; TD = typically developing; f o = fundamental frequency; F = female; M = male.