a, Proteomic subtypes were identified in 40 matched pGBM-rGBM pairs. Clinical covariates indicating tumour classification, age at treatment (years), transcriptomic subtype, sex and pathway enrichment for proteomic subtypes are shown. b, pGBM and rGBM samples from the same patient classify as different proteomic (n = 40; replicate pGBM or rGBM samples were removed for simplicity) and c, transcriptomic subtypes (n = 22).