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. 2023 Mar 13;9(3):1134–1142. doi: 10.1002/vms3.1105

FIGURE 4.

FIGURE 4

ADMSC‐EVs protect renal IR from histological lesions (a, b), oxidative stress (c), mitochondrial damage (a) and cell apoptosis (a, d). ADMSC‐EVs can protect against histological lesions, cell apoptosis, mitochondrial damage after 30h renal IR to alleviate renal IR (a). Renal tubule injury was evaluated by Paller scoring standard (b). The administration of ADMSC‐EVs resulted in reducing renal oxidative stress (SOD, MPO, MDA) to alleviate renal IR (c). IR‐induced cell apoptosis was largely alleviated after ADMSC‐EVs treatment (d). Positive rate = number of positive cells/total number of cells × 100%, **p < 0.01, *p < 0.05.