Fig. 3.

Higher mitochondrial superoxide in the lungs of LPS-treated mice compared to control and higher in EC-SOD KO mice compared to WT. Mice were treated with LPS (10 mg/kg, intraperitoneal (IP) injection). After 24 h mice were injected with DCP-AM-H (IP) with lung harvest 1 h later. See Materials and Methods for details. (a) Concentration of nitroxide DCP• in the lungs of PBS-treated mice and LPS-treated mice. (b) Concentration of nitroxide DCP• in the lungs of LPS-treated EC-SOD KO and WT mice. Data expressed as mean ± SEM; *p < 0.05 (n = 5–9)