Figure 1.
Combination plot of effect size against significance level in biomarkers between GD and healthy controls. X-axis: effect size estimated by omega squared (ω2). Y-axis: significance level as −log 10 (adjusted P value). Blue line: represents significance level at P = .01. Blue dots: biomarker suppressed in GD. Red dots: biomarker elevated in GD. ω2 and P values for difference in biomarkers were obtained from a linear regression model, adjusted for age, BMI, and smoking. AA, anthranilic acid; BMI, body mass index; CRP, C-reactive protein; FMN, flavin mononucleotide; GD, Graves disease; HK, 3-hydroxykynurenine; IAA, indole-3-acetate; IAld, indole-3-aldehyde; ILA, indole-3-lactate; IPA, indole-3-propionate; KA, kynurenic acid; KTR, kynurenine-tryptophan-ratio; Kyn, kynurenine; mNAM, N1-methylnicotinamide; NAM, nicotinamide; PA, 4-pyridoxic acid; Pic, picolinic acid; PL, pyridoxal; PLP, pyridoxal 5′-phosphate; QA, quinolinic acid; Qld, quinaldic acid; Ribo, riboflavin; SAA, serum amyloid A; S100A, calprotectin; Trp, tryptophan; XA, xanthurenic acid; 3IS, 3-indoxyl sulfate.