Extended Data Fig. 6. Product purity of CBE-Ts relative to BE4.
a, Product distribution of sequencing reads mapped as edited for core CBE-Ts and BE4, in which the specified target cytosine (highlighted in red) is mutated. Values were determined from transfection of HEK293T with mRNA at saturating conditions. Values and error bars reflect the mean and SD at n = 3 independent biological replicates performed on different days. b, Color map of maximum C·G to T·A conversions outside and 5′ of the protospacer target window. Target site positions where >0.8% C-to-T editing was detected for any editor are included. Values were determined from transfection of HEK293T with mRNA encoding editors or controls at saturating conditions, with n = 4 independent biological replicates performed on different days.