Table 3.
The univariable and multivariate logistic regression analysis of cancer-specific early death
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p-value | OR | 95% CI | p-value | |
| Sex | ||||||
| Female | Reference | |||||
| Male | 0.64 | 0.48–0.87 | 0.005 | 0.99 | 0.69–1.42 | 0.963 |
| Age(years) | ||||||
| < 50 | Reference | |||||
| 50–59 | 2.88 | 0.63–13.27 | 0.174 | 3.11 | 0.65–14.94 | 0.157 |
| 60–69 | 4.4 | 1.03–18.71 | 0.045 | 4.65 | 1.05–20.58 | 0.043 |
| 70–79 | 6.39 | 1.54–26.51 | 0.011 | 6.31 | 1.46–27.26 | 0.014 |
| 80–89 | 14.19 | 3.46–58.13 | < 0.001 | 10.69 | 2.49–45.94 | 0.001 |
| ≥ 90 | 14.96 | 3.25–68.92 | 0.001 | 8.21 | 1.65–40.76 | 0.010 |
| Race | ||||||
| White | Reference | |||||
| Black | 1.1 | 0.66–1.85 | 0.713 | |||
| Other | 0.77 | 0.46–1.27 | 0.301 | |||
| Marital | ||||||
| Married | Reference | |||||
| UnMarried | 1.85 | 1.35–2.52 | < 0.001 | 1.31 | 0.91–1.89 | 0.142 |
| Unknown | 1.05 | 0.41–2.65 | 0.922 | 0.77 | 0.27–2.21 | 0.626 |
| Tumor number | ||||||
| 2 | Reference | |||||
| ≥ 3 | 1.54 | 0.92–2.6 | 0.103 | |||
| Tumor position | ||||||
| Unilateral group | Reference | |||||
| Bilateral group/ rectum-colon synchronous group | 1.12 | 0.81–1.55 | 0.505 | |||
| Histology | ||||||
| AC | Reference | |||||
| MAC/ SRCC | 1.6 | 1.09–2.34 | 0.016 | 1.28 | 0.83–1.96 | 0.265 |
| Grade | ||||||
| Well/moderately | Reference | |||||
| Poorly/undifferentiated | 2.15 | 1.57–2.94 | < 0.001 | 1.6 | 1.12–2.29 | 0.010 |
| Unknown | 1.66 | 0.75–3.69 | 0.21 | 2.11 | 0.85–5.23 | 0.105 |
| T stage | ||||||
| T1/2 | Reference | |||||
| T3 | 1.84 | 1.11–3.04 | 0.017 | 1.3 | 0.74–2.27 | 0.362 |
| T4 | 4.11 | 2.37–7.14 | < 0.001 | 2.23 | 1.16–4.29 | 0.016 |
| TX | 8.41 | 4.44–15.93 | < 0.001 | 1.57 | 0.69–3.59 | 0.280 |
| N stage | ||||||
| N0 | Reference | |||||
| N1 | 2.12 | 1.47–3.06 | < 0.001 | 2.11 | 1.4–3.17 | < 0.001 |
| N2 | 3.26 | 2.24–4.75 | < 0.001 | 2.9 | 1.82–4.63 | < 0.001 |
| NX | 1.32 | 0.17–9.99 | 0.789 | 0.56 | 0.06–4.82 | 0.596 |
| M stage | ||||||
| M0 | Reference | |||||
| M1 | 5 | 3.64–6.85 | < 0.001 | 5.22 | 3.38–8.07 | < 0.001 |
| Tumor size(mm) | ||||||
| ≤ 50 | Reference | |||||
| > 50 | 1.75 | 1.28–2.39 | 0.001 | 1.42 | 0.99–2.02 | 0.054 |
| Unknown | 0.94 | 0.51–1.71 | 0.834 | 1.47 | 0.75–2.89 | 0.264 |
| Chemotherapy | ||||||
| Yes | Reference | |||||
| No/Unknown | 4.73 | 2.95–7.57 | < 0.001 | 6.7 | 3.93–11.42 | < 0.001 |
| Radiotherapy | ||||||
| Yes | Reference | |||||
| No/Unknown | 11.86 | 2.93–48.02 | 0.001 | 5.05 | 1.14–22.34 | 0.033 |
| Surgery | ||||||
| Non-extensive excision | Reference | |||||
| Extensive resection | 1.24 | 0.8–1.91 | 0.344 | |||
Extensive resection: total colectomy or total proctocolectomy; non-extensive excision: segmental rection, subtotal colectomy, left and right hemicolectomy, total proctectomy
AC adenocarcinoma, MAC mucinous or mucin-producing adenocarcinoma, SRCC signet ring cell carcinoma