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. 2023 Jan 4;46(3):893–911. doi: 10.1007/s10753-022-01778-y

Fig. 4.

Fig. 4

Modulation of PGE2 synthesis by EP-2/4 agonist, TNFα, and native LDL in THP-1 macrophages. THP-1 monocytes were differentiated, cultured, and stimulated as described in the legend of Fig. 3. PGE2 concentration in the supernatant of the cells was measured by competitive sandwich ELISA. Data shown are means ± SEM of at least five independent experiments performed in triplicate. Statistics: two-way ANOVA with Tukey’s multicomparison test: a, significantly higher than control; b, significantly higher than without 500 µg/ml LDL (p < 0.05).