Table 4.

Standardised mortality ratios (SMR) and 95% confidence intervals (Cis) of cancer subtypes in all individuals exposed to proton pump inhibitors, stratified by sex and age groups

	Gastrointestinal cancers		Non-gastrointestinal Cancers
	Number of deaths	SMR (95% CI)	Number of deaths	SMR (95% CI)
Total	10,330	1.45 (1.42–1.48)	17,676	1.11 (1.09–1.13)
Sex
Men	5273	1.64 (1.59–1.68)	8283	1.10 (1.07–1.12)
Women	5057	1.29 (1.26–1.33)	9393	1.12 (1.10–1.14)
Age groups
20–39	65	9.88 (7.62–12.49)	210	8.83 (7.67–10.10)
40–49	252	4.42 (3.89–5.00)	454	2.88 (2.61–3.15)
50–59	910	2.70 (2.53–2.89	1489	1.91 (1.81–2.01)
60–69	2415	1.86 (1.79–1.94)	4095	1.40 (1.36–1.45)
≥ 70	6688	1.23 (1.20–1.26)	11,428	0.95 (0.93–0.97)
Gastrointestinal cancer subtypes
Colorectal	3373	1.19 (1.15–1.23)
Pancreas	2587	1.50 (1.45–1.56)
Liver, gallbladder and bile ducts	1724	1.52 (1.45–1.59)
Stomach	1312	1.91 (1.81–2.01)
Oesophagus	841	2.09 (1.95–2.24)
Other gastrointestinal	493	1.38 (1.26–1.51)