Fig. 1.
FMR1 deletion results in sex-dependent effects on fat and lean body mass in aged mice and increased bone mass in young and aged male and female FMR1-deficient mice. Animals were weighed and body composition (a, b) and BMD (c, d) were measured by Dxa/Piximus at 2 (a, c) and 9 (b, d) months of age. Data are presented as minimum to maximum box and whiskers, with box boundaries indicating 25th to 75th percentile and horizontal lines, the median, and each dot corresponding to an individual sample. *P < 0.05 vs. FMR1y/+ mice for males by student’s t-test and vs. FMR1+/+ by one way ANOVA for females. Detailed statistical analyses are included in Table S1 (males) and S2 (females). Numbers above the graphs indicate sample size for each measurement. BMD: bone mineral density