Table 1.

Effect of 600-HPTChC₆₅ on permeability of [³H]-digoxin across the Caco-2 monolayers.

Treatment	Papp(AP-to-BL) (× 10−3 cm.min−1)	Papp(BL-to-AP) (× 10−3 cm.min−1)	Efflux ratio (ER)
Non-treated	0.14 ± 0.01	1.41 ± 0.06	10.1 ± 0.4
Verapamil 100 µM	0.34 ± 0.03#	0.52 ± 0.06#	1.6 ± 0.1#
600-HPTChC65 0.08% (w/v)	0.24 ± 0.02*	1.20 ± 0.05*	5.2 ± 0.6*
600-HPTChC65 0.16% (w/v)	0.21 ± 0.02*	1.14 ± 0.03*	5.6 ± 0.7*
600-HPTChC65 0.32% (w/v)	0.19 ± 0.03	1.08 ± 0.06*	5.8 ± 0.5*

Data are expressed as the apparent permeability coefficient (Papp) and efflux ratio (ER) (mean ± SEM, n = 4). The efflux ratio (ER) is the ratio of P_{app(BL-to-AP)} to P_{app(AP-to-BL)}.

* and ^# represent significant difference (p < 0.05), (Student’s t-test for verapamil vs non-treated; one-way ANOVA with post-hoc Dunnett’s test for 600-HPTChC65 vs non-treated).