Table 2.
Ongoing clinical trials of EVs/exosomes for treatment of brain diseases
| EVs/Exosomes | Sponsor/organization | Administration route | Brain disease | Reference |
|---|---|---|---|---|
| miR-124-Loaded MSC-Exos | Saeed Oraei Yazdani | intranasal | acute ischemic stroke |
NCT03384433 phase 1 phase 2 |
| Adipose MSC-exos | Ruijin Hospital, Shanghai Jiao Tong University | stereotaxis/intraparenchymal | Alzheimer’s disease |
NCT04388982 phase 1 phase 2 |
| Neonatal stem cell-Exos | Neurological Associates of West Los Angeles | intravenously, epineural using ultrasound guidance | craniofacial neuralgia | NCT04202783 |
| Allogenic exosomes | Neurological Associates of West Los Angeles | ultrasound delivery of exosomes | refractory depression, anxiety disorders, neurodegenerative diseases | NCT04202770 |