TABLE 7.
Studies reporting use of analgesic antipyretic agents from 2009 (k = 100) and 2019 (k = 100) included in the subset of 200 studies.
| References | Species used | Drug | Administration route | Dosage (mg/kg) |
Timepoint of first administration | Administered how many times in total | Administration interval (h post first administration) |
| Gurevicius et al., 2009 | Mice | Carprofen | i.p. | 5 | Postsurgically | 1 | n.a. |
| Magloire and Cattarelli, 2009 | Rats | Acetaminophen | per os | n.r. | Postsurgically | n.a. | n.a. |
| Schei et al., 2009 | Rats | Flunixin | s.c. | 1,1 | Intrasurgically | 1 | n.a. |
| Shultz et al., 2009 | Rats | Ketoprofen | s.c. | n.r. | Postsurgically | 1 | n.a. |
| Topchiy et al., 2009 | Rats | Flunixin | n.r. | 1,1 | Postsurgically | 3 | 24 |
| Bazzu et al., 2019 | Mice | Meloxicam | s.c. | 1 | Presurgically | 1 | n.a. |
| Christiaen et al., 2019 | Rats | Meloxicam | s.c. | 1 | Postsurgically | 2 | n.a. |
| Farakhor et al., 2019 | Rats | Meloxicam | n.r. | 0,2 | Postsurgically | 4 | 24h post-surgery |
| Kaefer et al., 2019 | Rats | Meloxicam | n.r. | 5 | Intrasurgically | 1 | n.a. |
| Mastrella et al., 2019 | Mice | Carprofen | i.p. | 2 to 4 | Presurgically | 7 | n.a. |
| Mohammad et al., 2019 | Rats | Ketoprofen | s.c. | 5 | Presurgically | 4 | n.a. |
| Moller et al., 2019 | Rats | Meloxicam | s.c. | 1 | Presurgically | 2 | 24h post-surgery |
| O’Brien et al., 2019 | Mice | Carprofen | n.r. | n.r. | Postsurgically | n.r. | n.r. |
| Park et al., 2019 | Mice | Meloxicam + acetaminophen |
Meloxicam s.c. acetaminophen per os |
Meloxicam 1 acetaminophen n.r. |
Postsurgically | 1 | n.a. |
| Sa et al., 2019 | Rats | Ketoprofen | s.c. | n.r. | Postsurgically | 1 | n.a. |
| Shaver et al., 2019 | Rats | Ketoprofen | s.c. | 5 | Presurgically | 1 | n.a. |
| Souza et al., 2019 | Rats | Ketoprofen | s.c. | 3 to 5 | Postsurgically | 4 | n.a. |
| Sun et al., 2019 | Mice | Ketoprofen | i.p. | 5 | Presurgically | 1 | n.a. |
| Szonyi et al., 2019 | Mice | Meloxicam | i.p. | 0,03 to 0,05 | Postsurgically | 1 | n.a. |
| Wang et al., 2019f | Mice | Carprofen | s.c. | 20 | Postsurgically | 4 | n.a. |
| Wen et al., 2019 | Rats | Meloxicam | n.r. | 2 | Presurgically | 1 | n.a. |
Information on studies reporting use of analgesic antipyretic agents [non-steroidal anti-inflammatory drugs (NSAIDs) and antipyretic analgesics] (5 studies in 2009; 16 studies in 2019) included in the subset of 200 studies. n.r., not reported, parameter was not reported; n.a., not applicable, extraction of this parameter was not feasible; i.p., intraperitoneal; i.m., intramuscular; s.c., subcutaneous; numbers in the study ID (e.g., Souza et al., 2019) indicate animal groups within individual studies.