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EGF (and its homologs) attachment to EFGR causes direct or indirect cascades of events that result in cell viability and cell proliferation. The main characteristics of cancer progression-increased growth, decreased apoptosis, enhanced angiogenesis, and metastasis are associated with somatic EGFR mutations that result in sustained activation. The illustration highlights the method for suppressing abnormal EGFR activation in tumor cells utilizing tyrosine kinase inhibitors.
