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. 2023 May 3;14:1174330. doi: 10.3389/fphar.2023.1174330

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Copyright © 2023 Bhattacharjee, Syeda, Rynjah, Hussain, Chandra Bora, Pegu, Sahu and Khan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Infographic depicting how stimulation of the JAK/STAT signaling cascade induces the overexpression of genes associated with proliferation and tumor angiogenesis. The JAK/STAT pathways go through a number of cycles: 1: Cytokines adhere to receptors, which further crosslink. 2: Phosphorylation of JAKs on one another. 3: Phosphorylation of the receptor through JAKs, creating phosphotyrosine interacting regions for STAT SH2 motif. 4: STAT interacts with the receptor. Phosphorylation of the STAT via JAK changes the structure of STAT. 5: The dissociation of STAT phosphorylation from the receptor and cross-linking. 6: The STAT phosphorylation immediately moves inside the nucleus. 7: STAT phosphorylation interacts with DNA. 8: Activation of DNA transcription of target genes.