Table 2.
Number of lymphomas and incidence rates in the included studies of lymphoma in IBD.
| References | Country | Male-to-female ratio | Diagnosis | Observed lymphomas (n) | Incidence rate | Standard error | 95% CI lower bound | 95% CI upper bound |
|---|---|---|---|---|---|---|---|---|
| Abbas et al. (27) | Canada | N/A | UC | 282 | 80.0 | 4.8 | 70.7 | 89.3 |
| Beaugerie et al. (6) | France | 3/3 | IBD | 6 | 26.4 | 10.8 | 5.3 | 47.5 |
| CD | 3 | 27.5 | 15.9 | −3.6 | 58.6 | |||
| UC | 3 | 25.4 | 14.7 | −3.3 | 54.1 | |||
| Bernstein et al. (28) | Canada | N/A | IBD | 16 | 39.9 | 9.8 | 19.9 | 58.1 |
| CD | 9 | 42.2 | 11.7 | 14.6 | 69.8 | |||
| UC | 7 | 35.6 | 15.8 | 9.2 | 62.0 | |||
| Biancone et al. (29) | Italy | N/A | IBD | 6 | 45 | 18.3 | 9 | 81 |
| CD | 6 | 91 | 37.2 | 18 | 164 | |||
| UC | 0 | 0.0 | 0.0 | 3.7 | ||||
| Biancone et al. (30) | Italy | 9/2 | IBD | 11 | 45 | 13.77 | 18 | 72 |
| CD | 11 | 89 | 27.3 | 36 | 143 | |||
| UC | 0 | 0.0 | 0.0 | 3.7 | ||||
| Caini et al. (31) | Italy | N/A | IBD | 2 | 97.2 | 59.2 | 0.0 | 232 |
| CD | 0 | 0.0 | 0.0 | 3.7 | ||||
| UC | 2 | 13.0 | 7.9 | 0.0 | 31 | |||
| Campos et al. (32) | Brasil | 3/0 | CD | 2 | 43 | 5.86 | 0.0 | 23 |
| UC | 1 | 15.8 | 3.06 | 0.0 | 12 | |||
| Chiorean et al. (33) | USA | 5/3 | IBD | 8 | 26.6 | 9.4 | 8.2 | 45.0 |
| CD | 5 | 26.1 | 11.7 | 3.2 | 49.0 | |||
| UC | 3 | 27.3 | 15.8 | −3.6 | 58.2 | |||
| de Francisco et al. (34) | Spain | 3/3 | IBD | 6 | 89 | 34.4 | 17 | 160 |
| CD | 5 | 12 | 5.48 | 1.5 | 23 | |||
| UC | 1 | 33 | 25.5 | 0 | 100 | |||
| Farrell et al. (35) | Ireland | 3/1 | IBD | 4 | 64.0 | 32.0 | 1.3 | 126.7 |
| Fraser et al. (36) | New Zealand | 4/1 | IBD | 5 | 9.0 | 4.0 | 1.1 | 16.9 |
| CD | 1 | 4.87 | 4.9 | −4,7 | 14.4 | |||
| UC | 4 | 11.5 | 5.8 | 0.2 | 22.8 | |||
| Greenstein et al. (37) | USA | 5/1 | IBD | 6 | 13.9 | 5.7 | 2.7 | 25 |
| CD | 3 | 11.1 | 6.04 | 0.0 | 23.7 | |||
| UC | 3 | 18.6 | 10.1 | 0.0 | 39.6 | |||
| Herrinton et al. (9) | USA | 28/5 | IBD | 33 | 48.6 | 8.5 | 32.0 | 65.2 |
| Jess et al. (38) | Denmark | 0 | CD | 0 | 0.00 | 0.0 | 3.7 | |
| Jess et al. (39) | Denmark | N/A | IBD | 15 | 44.3 | 11.4 | 21.9 | 66.7 |
| CD | 7 | 62.2 | 23.5 | 16.1 | 108.3 | |||
| UC | 8 | 35.4 | 12.5 | 10.9 | 59.9 | |||
| Jung et al. (40) | Korea | 0/5 | IBD | 5 | 16.3 | 7.32 | 2 | 30.7 |
| CD | 3 | |||||||
| UC | 2 | |||||||
| Jussila et al. (41) | Finland | 41/17 | IBD | 72 | 31.0 | 3.7 | 23.8 | 38.2 |
| CD | 14 | 27.0 | 7.2 | 12.9 | 41.1 | |||
| UC | 58 | 32.1 | 4.2 | 23.8 | 40.4 | |||
| Khan et al. (42) | USA | 119/0 | UC | 119 | 60.0 | 5.5 | 49.2 | 70.8 |
| Khan et al. (43) | USA | N/A | IBD | 65 | 50 | 6.3 | 38 | 63 |
| Kobayashi et al. (44) | Japan | N/A | IBD | 103 | 54 | 5.38 | 43.9 | 65 |
| Kopylov et al. (45) | Canada | 0/59 | IBD | 121 | 12 | 1.02 | 10 | 14 |
| Lakatos et al. (46) | IBD | 3 | 15.5 | 8.9 | −2.0 | 33.0 | ||
| CD | 1 | 14.1 | 14.1 | −13.5 | 41.7 | |||
| UC | 2 | 15.6 | 11.0 | −6.0 | 37.2 | |||
| Lemaitre et al. (13) | France | 192/144 | IBD | 336 | 26.5 | 1.53 | 23 | 29 |
| Lewis et al. (57) | UK | 7/8 | IBD | 18 | 28.0 | 6.6 | 15.1 | 40.9 |
| CD | 7 | 28.9 | 10.9 | 7.5 | 50.3 | |||
| UC | 11 | 27.5 | 8.3 | 11.2 | 43.8 | |||
| Loftus et al. (11) | USA | N/A | IBD | 1 | 15.0 | 15.0 | −14.4 | 44.4 |
| CD | 1 | 32.0 | 32.0 | −30.7 | 94.7 | |||
| UC | 0 | 0 | 0.0 | 3.7 | ||||
| Madanchi et al. (47) | Switzerland | N/A | IBD | 5 | 32 | 14.2 | 4 | 60 |
| CD | 4 | 43 | 21.9 | 0.8 | 87 | |||
| UC | 1 | 15.8 | 11.7 | 0.0 | 46 | |||
| Mellemkjær et al. (48) | Denmark | N/A | CD | 4 | 17.5 | 8.8 | 0.4 | 34.7 |
| Mizushima et al. (49) | Japan | 0 | CD | 0 | 0.0 | 0.0 | 3.7 | |
| Palli et al. (50) | Italy | 3/2 | IBD | 7 | 66.0 | 24.9 | 17.1 | 114.9 |
| CD | 1 | 36.8 | 36.8 | −35.3 | 108.8 | |||
| UC | 6 | 76.2 | 31.1 | 15.2 | 137.2 | |||
| Pasternak et al. (4) | Denmark | N/A | IBD | 46 | 15.1 | 2.2 | 10.7 | 19.5 |
| Ranjan et al. (51) | India | 0 | IBD | 0 | 0.0 | 0.0 | 3.7 | |
| CD | 0 | 0.0 | 3.7 | |||||
| UC | 0 | 0.0 | 3.7 | |||||
| Scharl et al. (52) | Switzerland | N/A | IBD | 103 | 33.02 | 3.26 | 26.6 | 39.4 |
| van den Heuvel et al. (53) | Netherlands | N/A | IBD | 3 | ||||
| Van Domselaar et al. (54) | Spain | 5/2 | IBD | 7 | 81.7 | 30.9 | 21.2 | 142.2 |
| Winther et al. (55) | New Zealand | N/A | UC | 2 | 17.9 | 12.7 | −6.9 | 42.8 |
| Yano et al. (56) | Japan | 0 | CD | 0 | 0.0 | 0.0 | 3.7 |