Table 4.
Univariable and multivariable Cox regression analyses for time to PFS.
| Characteristics | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Therapy options (HAIC+T vs. HAIC+T+P) | 2.079 (1.382–3.126) | <0.001 | 2.175 (1.438–3.289) | <0.001 |
| Age (years) | 1.004 (0.985–1.022) | 0.702 | ||
| Sex (male vs. female) | 1.155 (0.643–2.073) | 0.630 | ||
| Etiology of HCC and HBV (vs. others) | 2.362 (1.310–4.259) | 0.004 | 1.824 (0.981–3.395) | 0.058 |
| Child–Pugh score (7–9 vs.5–6) | 1.573 (1.027–2.409) | 0.037 | 1.612 (1.044–2.492) | 0.031 |
| Cirrhosis (no vs. yes) | 0.998 (0.799–1.245) | 0.984 | ||
| BCLC stage (C vs. B) | 1.134 (0.753–1.708) | 0.546 | ||
| Portal vein invasion (no vs. yes) | 0.977 (0.649–1.473) | 0.913 | ||
| Tumor numbers (≤3 vs. >3) | 0.936 (0.433–2.025) | 0.867 | ||
| Largest tumor diameter (per cm) | 1.042 (0.988–1.099) | 0.127 | ||
| AFP (ng/ml; ≤400 vs. >400) | 0.908 (0.632–1.304) | 0.600 | ||
| Extrahepatic metastases (yes vs. no) | 1.136 (0.748–1.723) | 0.550 | ||
| APFs (no vs. yes) | 0.536 (0.352–0.814) | 0.003 | 0.546 (0.354–0.841) | 0.006 |
HR, hazards ratio; CI, confidence interval; HAIC, hepatic artery infusion chemotherapy; HBV, hepatitis B virus; BCLC, Barcelona Clinic Liver Cancer; AFP, alpha-fetoprotein; CA199, carbohydrate antigen 199; APFs, arterioportal fistulas.
The bold values denote statistical significance at P < 0.05 level.