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. 2023 May 3;14:1162669. doi: 10.3389/fimmu.2023.1162669

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Copyright © 2023 Bowen, Deng, Reyes-Uribe, Parra, Rocha, Solis, Wistuba, Sepeda, Vornik, Perloff, Szabo, Umar, Sinha, Brown and Vilar

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphical abstract of study design and workflow. The panel illustrates the schematic of experimental design and workflow used in this study. Normal rectosigmoid colon biopsies were collected from 18 LS participants [placebo N=6, low dose (LD, 220 mg) N=6, high dose (HD, 440 mg) N=6]. Participants (N=18) provided a pre- and post-exposure biopsy samples (N=36 samples) for tissue micro array (TMA), which was used for image mass cytometry (IMC) and analysis. This figure was generated using BioRender.com.