Table 1.
Overview of human and mouse chemokines
| Human | Mouse | |||||
|---|---|---|---|---|---|---|
| Symbol | Location | Aliases | Receptor(s) | Symbol | Aliases | Receptor(s) |
| CC | ||||||
| CCL1 | 17q12 | I-309, TCA3,P500,SISe | CCR8, ACKR1 | Ccl1 | TCA-3 | Ccr8 |
| CCL2 | 17q12 | MCP1, MCP-1, SCYA2, MCAF, SMC-CF, GDCF-2, HC11, MGC9434 | CCR2, CCR4, CCR5, ACKR1, ACKR2, ACKR4 | Ccl2 | JE, MCP-1 | Ccr2, Ccr4, Ackr1, Ackr2 |
| Ccl12 | MCP-5, Scya12 | Ccr2 | ||||
| CCL3 | 17q12 | MIP-1-alpha, MIP1A, SCY3, G0S19-1, LD78ALPHA | CCR1, CCR2, CCR4, CCR5, ACKR2 | Ccl3 | MIP-1 alpha | Ccr1, Ccr4, Ccr5, Ackr2 |
| CCL3L1 | 17q12 | MIP1AP, LD78BETA, G0S19-2 | CCR1, CCR3, CCR5, ACKR2 | |||
| CCL3L3 | 17q12 | LD78BETA, MGC12815 | CCR1, CCR3, CCR5, ACKR2 | |||
| CCL4 | 17q12 | MIP-1-beta, ACT-2, AT744.1 | CCR1, CCR3, CXCR4, CCR5, CCR8, ACKR2 | Ccl4 | MIP-1 beta, AT744.1, Act-2 | CCR1, CCR5 |
| CCL4L1 | 17q12 | LAG-1, MIP-1-beta, AT744.2 | CCR1, CCR5 | |||
| CCL4L2 | 17q12 | AT744.2, CCL4 L, SCYA4 L | CCR1, CCR5 | |||
| CCL5 | 17q12 | RANTES, SISd, TCP228, MGC17164 | CCR1, CCR3, CCR4, CCR5, ACKR1, ACKR2 | Ccl5 | Rantes | Ccr1, Ccr3, Ccr4, Ccr5 |
| CCL7 | 17q12 | MCP-3, NC28, FIC, MARC, MCP3 | CCR1, CCR2, CCR3, CCR5, CXCR3, ACKR1, ACKR2 | Ccl7 | MARC, FIC, MCP-3 | Ccr1, Ccr2, Ccr3 |
| CCL8 | 17q12 | MCP-2, HC14 | CCR1, CCR2, CCR3, CCR5, ACKR2, ACKR1, ACKR4 | Ccl8 | MCP-2, HC14, Scya8 | Ccr8, Ackr1, Ackr2 |
| CCL11 | 17q12 | Eotaxin | CCR3, CCR5, ACKR1, ACKR2, CXCR3 | Ccl11 | Eotaxin | Ccr3, Ackr1 |
| CCL13 | 17q12 | MCP-4, NCC-1, SCYL1, CKb10 | CCR1, CCR2, CCR3, CCR5, ACKR2, ACKR1, ACKR4 | |||
| CCL14 | 17q12 | HCC-1, HCC-3, NCC-2, SCYL2 CKb1, MCIF | CCR1, CCR3, CCR5, ACKR1, ACKR2, ACKR4 | |||
| CCL15 | 17q12 | HCC-2, NCC-3, SCYL3, MIP-5, LKN-1, MIP-1D, HMRP-2B | CCR1, CCR3 | Ccl9 | MIP-1 gamma, CCF18, MRP-2 | Ccr1, Ccr3 |
| CCL16 | 17q12 | HCC-4, SCYL4, LEC, NCC-4, LMC, LCC-1, CKb12, Mtn-1 | CCR1, CCR2, CCR3, CCR5, CCR8, ACKR1 | |||
| CCL17 | 16q21 | TARC, ABCD-2 | CCR4, CCR8, ACKR1, ACKR2 | Ccl17 | Tarc, Abcd-2 | Ccr4 |
| CCL18 | 17q12 | PARC, DC-CK1, AMAC-1, DCCK1, MIP-4, CKb7 | CCR8, PITPNM3, CCR3 | |||
| CCL19 | 9p13.3 | ELC, MIP-3b,exodus-3,CKb11 | CCR7, ACKR4, CCRL2 | Ccl19 | MIP-3 beta, ELC, Exodus-3 | Ccr7, Ackr4, CcrL2/LCCR |
| CCL20 | 2q36.3 | LARC, MIP-3a, exodus-1, ST38, CKb4 | CCR6 | Ccl20 | MIP-3 alpha, LARC, Exodus-1, | Ccr6 |
| CCL21 | 9p13.3 | SLC, exodus-2, TCA4, 6Ckine, ECL | CCR7, ACKR4 | Ccl21a | 6Ckine, Exodus-2, SLC, TCA-4, CK beta 9 | Ccr7, Ackr4 |
| Ccl21b | Ccr7 | |||||
| Ccl21d | Ccr7 | |||||
| CCL22 | 16q21 | MDC, STCP-1, ABCD-1, DC/B-CK | CCR4, ACKR2 | Ccl22 | ABCD-1, MDC, DC/beta-CK | Ccr4 |
| CCL23 | 17q12 | Ckb-8, MPIF-1, MIP-3, CKb8 | CCR1, CCR3, ACKR2 | Ccl6 | C10, MRP-1 | Ccr1 |
| CCL24 | 7q11.23 | Ckb-6, MPIF-2, Eotaxin-2, MPIF2 | CCR3, ACKR2 | Ccl24 | Eotaxin-2, MPIF-2, CK beta 6 | Ccr3 |
| CCL25 | 19p13.2 | TECK, Ckb15 | CCR9, ACKR4 | Ccl25 | TECK, CKbeta 15 | Ccr9, Ackr4 |
| CCL26 | 7q11.23 | Eotaxin-3, IMAC, MIP-4a | CCR3, CX3CR1, CCR2, CCR5 | Ccl26 | Ccl26 l, eotaxin-3 | |
| CCL27 | 9p13.3 | CTACK, ALP ILC, ESKINE, ESKY, CTAK | CCR10 | Ccl27a | Ccl27, CTACK, ALP, ILC, PESKY, Eskine | Ccr10 |
| Ccl27b | Ctack, Scya27b | Ccr3 | ||||
| CCL28 | 5p12 | SCYA28, MEC, CCK1 | CCR3, CCR10 | Ccl28 | MEC | Ccr10 |
| CXC | ||||||
| CXCL1 | 4q13.3 | SCYB1, GROa, MGSA-a, NAP-3 | CXCR2, ACKR1 | Cxcl1 | KC, Fsp, Gro1, GRO-alpha | Cxcr2, Ackr1 |
| CXCL2 | 4q13.3 | SCYB2, GROb, MIP-2a, MGSA-b, CINC-2a | CXCR2, ACKR1 | Cxcl2 | CINC-2a, Gro2, MIP-2 | Cxcr2, Ackr1 |
| CXCL3 | 4q13.3 | SCYB3, GROg, M IP-2b, CINC-2b | CXCR2, ACKR1 | Cxcl3 | Dcip1, Gm1960 | Cxcr2 |
| PF4 | 4q13.3 | CXCL4, oncostatin-A, iroplact | CXCR3, CXCR3B, ACKR1 | Pf4 | Cxcr3 | |
| PF4V1 | 4q13.3 | PCXCL1, CXCL4V1, PF4-ALT, PF4A | CXCR3, CXCR3B, ACKR1 | |||
| CXCL5 | 4q13.3 | ENA-78 | CXCR2, CXCR3B, ACKR1 | Cxcl5 | AMCF-II, Cxcl6, LIX, ENA-78, | Cxcr1, Cxcr2, Ackr1 |
| CXCL6 | 4q13.3 | GCP-2, CKA-3 | CXCR1, CXCR2, ACKR1 | |||
| CXCL7 | 4q13.3 | PPBP, THBGB1, NAP-2, CTAPIII, beta-TG | CXCR1, CXCR2, ACKR1 | Cxcl7 | Ppbp, NAP-2, CTAPIII, beta-TG | Cxcr1, Cxcr2 |
| CXCL8 | 4q13.3 | IL-8, SCYB8, LUCT, LECT, MDNCF, TSG-1, NAP-1,3-10 C, MONAP, AMCF-I, LYNAP, NAF, b-NAP, GCP-1, K60, GCP1, NAP1 | CXCR1, CXCR2, ACKR1 | |||
| CXCL9 | 4q21.1 | Mig, SCYB9, Humig, crg-10 | CXCR1, CXCR2, CXCR3, ACKR1, CCR3 | Cxcl9 | MIG, CRG-10 | Cxcr3 |
| CXCL10 | 4q21.1 | IFI10, IP-10, Crg-2, mob-1,C7,gIP-10 | CXCR3, CCR3 | Cxcl10 | CRG-2, IP-10 | Cxcr3 |
| CXCL11 | 4q21.1 | H174, b-R1,I-TAC,IP-9 | CXCR3, CXCR7, ACKR1, ACKR3, CCR3, CCR5 | Cxcl11 | I-TAC, beta-R1, H174, IP-9 | Cxcr3, Cxcr7 |
| CXCL12 | 10q11.21 | SCYB12, SDF-1, SDF-1b, PBSF, TLSF-a, TLSF-b, TPAR1 | CXCR4, ACKR2 | Cxcl12 | SDF-1, PBSF | Cxcr4, Cxcr7 |
| CXCL13 | 4q21.1 | BLC, BCA-1, BLR1 LANGIE, ANGIE2 | CXCR3, CXCR5, ACKR1 | Cxcl13 | BCA-1, BLC | Cxcr5 |
| CXCL14 | 5q31.1 | BRAK, NJAC, bolekine Kec, MIP-2 g, BMAC, KS1 | CXCR4 [14] | Cxcl14 | BRAK, BMAC Bolekine | Unknown |
| Cxcl15 | Lungkine, Weche | Unknown | ||||
| CXCL16 | 17p13.2 | SR-PSOX, CXCLG16, SRPSOX | CXCR6 | Cxcl16 | SR-PSOX | Cxcr6 |
| CXCL17 | 19q13.2 | Dcip1, UNQ473, DMC, VCC1 | Unknown | Cxcl17 | DMC, VCC-1 | Unknown |
| XC | ||||||
| XCL1 | 1q24.2 | Lymphotactin, LPTN, ATAC, SCM-1a, SCM-1 | XCR1 | Xcl1 | Lymphotactin | Xcr1 |
| XCL2 | 1q24.2 | SCM-1 beta | XCR1 | |||
| CX3C | ||||||
| CX3CL1 | 16q21 | Fractalkine, NTN, C3Xkine, ABCD-3, CXC3C, CXC3, DMC, VCC-1 | CX3CR1 | Cx3cl1 | Fractalkine, Neurotactin | Cx3cr1 |
Official gene names in which all letters are uppercase letters refer to human chemokines (left panel), and official gene names in which the first letter is uppercase and the rest are lowercase refer to murine chemokines (right panel). Alternate names in the ALIASES column shown in BOLD represent the most commonly recognized names. Receptors shown in BOLD are active or main receptor(s). The mouse chemokines homologous to human genes are listed in Table 2 [10–12, 14, 17–19, 46]