Table 2.
Orthologous chemokine genes between humans and mice
| Orthologous gene pair | Functional information | |
|---|---|---|
| Human gene | Murine gene | Shared recptor(s) |
| CCL1 | Ccl1 | CCR8 |
| CCL2 | Ccl12 | CCR2 |
| CCL3 | \ | \ |
| CCL3L1 | \ | \ |
| CCL3L3 | Ccl3 | CCR1; CCR5 |
| CCL4 | Ccl4 | CCR1; CCR5 |
| CCL4L1 | \ | \ |
| CCL4L2 | \ | \ |
| CCL5 | Ccl5 | CCR1; CCR3; CCR4; CCR5 |
| CCL7 | \ | \ |
| CCL8 | \ | \ |
| CCL11 | Ccl11 | CCR3 |
| CCL13 | Ccl2 | CCR2; D6 |
| CCL14 | \ | \ |
| CCL15 | \ | \ |
| CCL16 | \ | \ |
| CCL17 | Ccl17 | CCR4 |
| CCL18 | \ | \ |
| CCL19 | Ccl19 | CCR7; CCR11 |
| CCL20 | Ccl20 | CCR6 |
| CCL21 |
Ccl21a Ccl21b Ccl21c |
CCR7; CCR11 |
| CCL22 | Ccl22 | CCR4 |
| CCL23 | \ | \ |
| CCL24 | Ccl24 | CCR3 |
| CCL25 | Ccl25 | CCR9; CCR11 |
| CCL26 | \ | \ |
| CCL27 | Ccl27b | CCR10 |
| CCL28 | Ccl28 | CCR10 |
| CXCL1 | \ | \ |
| CXCL2 | Cxcl1 | CXCR2 |
| CXCL3 | Cxcl2 | CXCR2 |
| PF4 | Pf4 | CXCR3 |
| PF4V1 | \ | \ |
| CXCL5 | \ | \ |
| CXCL6 | Cxcl5 | CXCR1; CXCR2 |
| CXCL7 | \ | \ |
| CXCL8 | \ | \ |
| CXCL9 | \ | \ |
| CXCL10 | Cxcl10 | CXCR3 |
| CXCL11 | \ | \ |
| CXCL12 | Cxcl12 | CXCR4; CXCR7 |
| CXCL13 | Cxcl13 | CXCR5 |
| CXCL14 | Cxcl14 | Unknown |
| CXCL16 | Cxcl16 | CXCR6 |
| CXCL17 | Cxcl17 | Unknown |
| XCL1 | Xcl1 | XCR1 |
| XCL2 | \ | \ |
| CX3CL1 | Cx3cl1 | CX3CR1 |
Orthologous chemokine genes between humans and mice were extracted from the NCBI HomoloGene database (https://www.ncbi.nlm.nih.gov/homologene/) via the R package “homologene”, which were mainly based on genetic information. Orthologous chemokine genes pairs with inconsistent names are BOLD. “Shared Receptor(s)” means that both human and murine ligands in the orthologous pair can bind to the same receptor(s), which reflects the functional similarity of homologous genes