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. 2021 Apr 28;13(4):984–994. doi: 10.1177/21925682211012323

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — mRNA expression of IL-1α, TNFα, collagen II, MMP-3, aggrecan, PLA2 genes at 1, 2, and 3 months postoperatively. As the postoperative time is prolonged, mRNA expression of IL-1α (A), TNFα (B), MMP-3 (E), and PLA2 (F) are all higher than that expressed by the normal control group, while mRNA expression of these genes in the bilateral ischemia group is particularly increased. Collagen II (C) and aggrecan (D) mRNA in the normal control group show high levels of expression, while mRNA expression of collagen II and aggrecan of the unilateral and bilateral ischemia samples were significantly reduced, and the lowest levels are expressed by the bilateral ischemia group (*P < .05, compared with control group).