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. 2023 May 8;59:101979. doi: 10.1016/j.eclinm.2023.101979

Table 4.

Meta-regression of spirometry results.

Linear meta-regression of spirometry measurements in MDR compared to DS-TB
Meta-regression Number of study populations Coefficients (95% CI)
FEV1 (L) 10 −0.17 (−0.66 to 0.33)
FEV1% predicted 11 −16.16 (−29.95 to −2.37)a
FVC (L) 9 −0.33 (−0.73 to 0.06)
FVC % predicted 10 −10.98 (−26.13 to 4.17)
FV1/FVC ratio 12 −0.07 (−0.15 to 0.02)
Logistic meta-regression of odds of abnormala spirometry results
Meta-regression Number of study populations Odds ratio (95% CI)
DS-TB 19 Reference
MDR-TB 19 3.97 (0.98–16.19)

Pooled estimates included all persons at risk for respiratory impairment (i.e., the denominator in these estimates was all persons post-TB in the studies reporting on post-TB respiratory impairment).

DS-TB, drug susceptible tuberculosis; MDR-TB, multidrug-resistant tuberculosis; FEV1, forced vital capacity in 1 s; FVC, forced vital capacity; %pred., percentage of predicted value; L, litres; CI, Confidence Interval.

a

Any type of spirometry abnormality including obstruction, restriction, or mixed pattern.