Table 4.
Linear meta-regression of spirometry measurements in MDR compared to DS-TB | ||
---|---|---|
Meta-regression | Number of study populations | Coefficients (95% CI) |
FEV1 (L) | 10 | −0.17 (−0.66 to 0.33) |
FEV1% predicted | 11 | −16.16 (−29.95 to −2.37)a |
FVC (L) | 9 | −0.33 (−0.73 to 0.06) |
FVC % predicted | 10 | −10.98 (−26.13 to 4.17) |
FV1/FVC ratio | 12 | −0.07 (−0.15 to 0.02) |
Logistic meta-regression of odds of abnormala spirometry results | ||
---|---|---|
Meta-regression | Number of study populations | Odds ratio (95% CI) |
DS-TB | 19 | Reference |
MDR-TB | 19 | 3.97 (0.98–16.19) |
Pooled estimates included all persons at risk for respiratory impairment (i.e., the denominator in these estimates was all persons post-TB in the studies reporting on post-TB respiratory impairment).
DS-TB, drug susceptible tuberculosis; MDR-TB, multidrug-resistant tuberculosis; FEV1, forced vital capacity in 1 s; FVC, forced vital capacity; %pred., percentage of predicted value; L, litres; CI, Confidence Interval.
Any type of spirometry abnormality including obstruction, restriction, or mixed pattern.