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. 2022 Dec 27;8(3):e10464. doi: 10.1002/btm2.10464

FIGURE 3.

FIGURE 3

Cell migration from MSC spheroids upon inclusion of PDGF‐BB. (a) Confocal images of spheroids cultured over time in hydrogels using growth media supplemented with rm‐PDGF‐BB (10 ng/ml). Green = actin cytoskeleton. Blue = nucleus. (b) Area per spheroid in SR or FR hydrogels for samples cultured in growth media supplemented with rm‐PDGF‐BB (10 ng/ml). Spheroids consisted of mouse bone marrow‐derived MSCs. **** and ns indicate p ≤ 0.0001 and statistically not significant (p > 0.05), respectively; Brown–Forsythe and Welch ANOVA tests, followed by Games‐Howell's multiple comparisons test. Data points represent individual spheroids, based on n = 178–804 spheroids analyzed per group from three to four biologically independent experiments.