Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 27;8(3):e10464. doi: 10.1002/btm2.10464

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Role of Rac1 and ROCK. (a) Confocal images of MSC spheroids encapsulated in FR hydrogels cultured in growth medium supplemented with NSC‐23766 (Rac1 GTPase inhibitor) and Y‐27632 (ROCK inhibitor). Green = actin cytoskeleton. Blue = nucleus. (b) Area per spheroid cultured over time in FR hydrogels, without or with inhibitors. **** indicates p ≤ 0.0001; Brown–Forsythe and Welch ANOVA tests, followed by Games–Howell's multiple comparisons test. Data points represent individual spheroids, based on n = 563–1333 spheroids analyzed per group from three to four biologically independent experiments.