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. 2023 Mar 17;8(3):e10509. doi: 10.1002/btm2.10509

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© 2023 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Cytoskeletal rearrangement and actomyosin contractility of BMSC in the dynamic condition. (a) Gene expression array of 155 markers encoding adhesion, migration, and cytoskeletal regulation factors. Differentially expressed genes (p < 0.05, DEGs) were plotted in the heatmap. Unit variance scaling was applied to ΔΔCT values, and rows were centered. (b) Gene set enrichment analysis using UniProt and Reactome database. Top 5 enriched keywords and top 10 enriched pathways were displayed. (c) RT‐qPCR analysis of Rho‐ROCK signaling down to myosin light chain kinase. (d, e) Antibody microarray of cytoskeletal regulators. (f) Enzymic activity of ROCK measured by phosphorylation of myosin phosphatase target subunit 1 (MYPT1). Statistical comparison between the static and dynamic conditions was performed by Student's t‐test. *p < 0.05; **p < 0.01; ***p < 0.001.