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. 2022 Dec 13;8(3):e10466. doi: 10.1002/btm2.10466

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© 2022 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of The American Institute of Chemical Engineers.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The changes in the oral microbiota induced by lipopolysaccharide (LPS) injection were not detected in the SPIO‐labeled PDLSCs (PC‐SPIO) group. (a) Comparison of the microbiota of the PRE and INF groups by 16S rRNA gene sequencing, including Taxon.PCA, Beta Weighted_Unifrac test, and Heatmap analysis (class level). (b) Taxon.PCA analysis of the microbiota from different groups of SD rats: Saline and INF.Saline; PC and INF.PC; and PC‐SPIO and INF.PC‐SPIO. (c) Beta Weighted_Unifrac test of the microbiota from different groups of SD rats: Saline and INF.Saline; PC and INF.PC; and PC‐SPIO and INF.PC‐SPIO. (d) Heatmap analysis (phylum level) of the microbiota from different groups of SD rats: Saline and INF.Saline; PC and INF.PC; and PC‐SPIO and INF.PC‐SPIO