S100A9 knockout attenuates inflammatory response in aged mice. (A–C) The interleukin 1β (IL-1β), IL-6, and tumor necrosis factor α (TNF-α) levels in the serum of mice in different groups (n = 6). (D) Representative Western blots of Phospho-P38 and P65 in the aortas from mice in different groups. The related statistical results were exhibited in (E) and (F) (n = 6). ns, not significant. *P < 0.05, ***P < 0.001, ****P < 0.0001.