Extended Table 1.
Individual baseline characteristics for the study population.
| HIV-1 subtype |
HLA class I alleles | Plasma HIV-1 RNA (copies/mL) |
CD4+ T cells (per mm3) |
ART regimen | Intact HIV-1 proviruses (copies/106 CD4+ T cells) |
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| A1 | A2 | B1 | B2 | C1 | C2 | |||||||
| ART-control (n=15) | 105 | C | 02:01:01G | 24:02:01G | 08:01:01G | 15:01:01G | 03:03:01G | 07:01:01G | 290,000 | NA | ABA, 3TC, DTG | 81,027.8 |
| 110 | D | 01:01:01G | 29:02:01G | 08:01:01G | 44:03:01G | 07:01:01G | 16:01:01G | 88,000 | 1,440 | TDF, 3TC, DTG | 11,479.5 | |
| 120 | B | 02:03:01 | 02:03:01 | 46:01:01 | 51:01:02 | 01:02:01G | 14:02:01G | 15,500 | 560 | FTC, 3TC, DTG | 12,443.0 | |
| 201 | C | 01:01:01G | 23:01:01G | 08:01:01G | 44:03:01G | 04:01:01G | 07:01:01G | 3,240,000 | 344 | ABA, 3TC, DTG | 3,927.7 | |
| 206 | CRF01 | 01:01:01G | 02:01:01G | 37:01:01G | 44:02:01G | 06:02:01G | 07:04:01G | 78,300 | 271 | FTC, 3TC, DTG | 2,516.9 | |
| 208 | CRF other | 02:02:01G | 02:01:01G | 14:02:01G | 58:02:01G | 06:02:01G | 08:02:01G | 31,800 | NA | ABA, 3TC, DTG | 2,813.5 | |
| 209 | B | 03:01:01G | 30:04:01G | 14:02:01G | 40:02:01G | 02:02:02G | 08:02:01G | 16,900 | 948 | TDF, 3TC, DTG | 1,144.6 | |
| 305 | B | 03:01:01G | 03:01:01G | 07:02:01G | 35:01:01G | 04:01:01G | 07:02:01G | 6,415 | 590 | TDF, FTC, DTG | 304.3 | |
| 306 | B | 11:01:01G | 24:02:01G | 18:01:01G | 35:03:01G | 04:01:01G | 07:01:01G | 4,194 | 710 | TDF, FTC, DTG | 926.2 | |
| 405 | F | 03:01:01G | 03:01:01G | 35:03:01G | 44:02:01G | 04:01:01G | 07:04:01G | 499,000 | 765 | TDF, FTC, DTG | 1,327.7 | |
| 407 | B | 23:01:01G | 26:01:01G | 49:01:01G | 53:01:01G | 04:01:01G | 07:01:01G | 29,200 | 394 | ABA, 3TC, DTG | NA | |
| 409 | B | 01:01:01G | 68:02:01G | 14:02:01G | 57:01:01G | 07:01:01G | 08:02:01G | 39,207 | 466 | TDF, FTC, DTG | 4,052.8 | |
| 410 | B | 02:01:01G | 24:02:01G | 07:02:01G | 15:01:01G | 03:03:01G | 07:02:01G | 128,052 | 886 | TDF, FTC, DTG | 13,254.8 | |
| 702 | D | 29:02:01G | 66:01:01G | 18:01:01G | 35:01:01G | 04:01:01G | 05:01:01G | 110,000 | 338 | ABA, 3TC, DTG | 14,043.8 | |
| 707 | CRF01 | 02:01:01G | 02:01:01G | 57:01:01G | 57:01:01G | 06:02:01G | 06:02:01G | 820 | 1,497 | TDF, FTC, DTG | 162.0 | |
| ART+3BNC117 (n=15) | 106 | CRF01 | 26:01:01G | 68:01:02G | 07:02:01G | 40:01:01G | 03:04:01G | 07:02:01G | 681,000 | 230 | TDF, 3TC, DTG | NA |
| 109 | D | 11:01:01G | 24:02:01G | 07:02:01G | 39:01:01G | 07:02:01G | 07:02:01G | 22,400 | 660 | TDF, FTC, DTG | 394.4 | |
| 125 | B | 23:01:01G | 26:01:01G | 08:01:01G | 40:01:01G | 03:04:01G | 07:01:01G | 42,700 | 290 | ABA, 3TC, DTG | 6,172.8 | |
| 126 | CRF01 | 02:06:01G | 11:01:01G | 15:21:01G | 38:02:01G | 04:03:01G | 07:02:01G | 71,900 | 320 | ABA, 3TC, DTG | 81,795.7 | |
| 135 | CRF01 | 24:07:01G | 33:03:07 | 15:01:01G | 44:03:02G | 04:01:01G | 07:01:01G | 33,800 | NA | TDF, FTC, DTG | 1,817.3 | |
| 205 | B | 01:01:01G | 02:01:01G | 08:01:01G | 37:01:01G | 06:02:01G | 07:01:01G | 413,000 | 984 | ABA, 3TC, DTG | 4,908.5 | |
| 210 | B | 01:01:01G | 24:02:01G | 08:01:01G | 39:06:02G | 07:02:01G | 07:01:01G | 100,000 | 700 | ABA, 3TC, DTG | 1,384.4 | |
| 211 | B | 11:01:01G | 11:01:01G | 18:01:01G | 51:01:01G | 07:01:01G | 15:13:01 | 65,700 | 414 | TDF, FTC, DTG | 8,776.8 | |
| 302 | CRF01 | 01:01:01G | 03:01:01G | 14:02:01G | 37:01:01G | 06:02:01G | 08:02:01G | 37,726 | 760 | TDF, FTC, DTG | 31,179.2 | |
| 401 | B | 02:01:01G | 30:02:01G | 07:05:01G | 44:02:01G | 02:02:02G | 15:05:01G | 33,700 | 661 | TDF, FTC, DTG | 4,478.9 | |
| 404 | A | 30:01:01G | 68:01:01G | 50:01:01G | 51:01:01G | 15:02:01G | 16:01:01G | 16,200 | 457 | TDF, FTC, DTG | 3,003.4 | |
| 412 | B | 02:01:01G | 23:01:01G | 35:01:01G | 49:01:01G | 04:01:01G | 07:01:01G | 4,190,000 | 525 | TAF, FTC, BIC | 25,230.8 | |
| 701 | B | 02:01:01G | 02:01:01G | 15:01:01G | 44:02:01G | 03:03:01G | 05:01:01G | 740 | 506 | ABA, 3TC, DTG | 351.4 | |
| 703 | CRF02 | 01:01:01G | 24:02:01G | 07:02:01G | 08:01:01G | 07:02:01G | 07:01:01G | 24,000,000 | 345 | TAF, FTC, DTG | 95,783.6 | |
| 704 | CRF01 | 01:01:01G | 24:02:01G | 44:02:01G | 57:01:01G | 05:01:01G | 06:02:01G | 56,800 | 631 | TDF, FTC, DTG | 30,287.2 | |
| ART+RMD (n=13) | 104 | B | 02:01:01G | 02:01:01G | 15:01:01G | 44:05:01G | 02:02:02G | 03:28 | 116,000 | 600 | TDF, 3TC, DTG | 601.6 |
| 108 | CRF01 | 11:01:01G | 11:01:01G | 40:01:01G | 51:01:01G | 07:02:01G | 14:02:01G | 21,061 | 1,333 | TDF, FTC, DTG | 585.0 | |
| 115 | B | 01:01:01G | 34:01:01G | 15:21:01G | 27:02:01G | 02:02:02G | 04:03:01G | 49,400 | 490 | TDF, FTC, DTG | NA | |
| 117 | B | 02:01:01G | 24:02:01G | 40:02:01G | 56:01:01G | 01:02:01G | 02:02:02G | 44,200 | 500 | TDF, 3TC, DTG | 134,766.0 | |
| 131 | C | 29:02:01G | 74:01:01G | 15:03:01G | 42:01:01G | 02:10:01G | 17:01:01G | 3,800 | 220 | TDF, FTC, DTG | 2,641.4 | |
| 202 | B | 01:01:01G | 01:01:01G | 07:02:01G | 08:01:01G | 07:02:01G | 07:01:01G | 141,000 | 354 | ABA, 3TC, DTG | 8,091.5 | |
| 204 | C | 03:01:01G | 29:02:01G | 07:02:01G | 37:01:01G | 06:02:01G | 07:02:01G | 437,000 | 383 | FTC, 3TC, DTG | 5,580.2 | |
| 207 | B | 01:01:01G | 03:01:01G | 08:01:01G | 15:01:01G | 07:01:01G | 15:05:01G | 43,900 | NA | ABA, 3TC, DTG | 4,270.7 | |
| 307 | CRF01 | 01:01:01G | 33:01:01G | 14:02:01G | 50:01:01G | 06:02:01G | 08:02:01G | 16,466 | 340 | TDF, FTC, DTG | 10,943.0 | |
| 403 | A | 01:01:01G | 24:02:01G | 08:01:01G | 58:01:01G | 03:16 | 07:01:01G | 14,600 | 513 | ABA, 3TC, DTG | 5,816.7 | |
| 406 | B | 01:01:01G | 25:01:01G | 08:01:01G | 18:01:01G | 07:01:01G | 12:03:01G | 968,000 | 266 | TDF, FTC, DTG | NA | |
| 705 | CRF01 | 02:01:01G | 03:01:01G | 07:02:01G | 40:01:01G | 03:04:01G | 07:02:01G | 110,000 | 346 | ABA, 3TC, DTG | NA | |
| 708 | CRF02 | 02:05:01G | 24:02:01G | 35:03:01G | 41:01:01G | 04:01:01G | 17:01:01G | 1,900,000 | 391 | ABA, 3TC, DTG | 29,484.6 | |
| ART+3BNC117+RMD (n=16) | 103 | B | 24:02:01G | 26:01:01G | 27:05:02G | 38:01:01G | 02:02:02G | 12:03:01G | 730 | 610 | TDF, 3TC, DTG | 190.5 |
| 107 | CRF01 | 02:01:01G | 25:01:01G | 15:01:01G | 44:02:01G | 03:03:01G | 05:03:01G | 188,945 | 470 | TDF, FTC, DTG | 3,144.5 | |
| 112 | G | 02:01:01G | 68:01:02G | 15:78:01 | 44:02:01G | 03:04:01G | 07:04:01G | 23,100 | 560 | TDF, 3TC, DTG | 10,599.5 | |
| 116 | C | 01:01:01G | 02:01:01G | 15:01:01G | 57:03:01G | 03:04:01G | 07:01:01G | 69,400 | 380 | ABA, 3TC, DTG | 212.3 | |
| 130 | CRF01 | 02:01:01G | 02:01:01G | 15:01:01G | 44:02:01G | 03:04:01G | 07:04:01G | 3,710 | 260 | TDF, 3TC, DTG | 26,738.8 | |
| 203 | CRF01 | 01:01:01G | 02:01:01G | 07:02:01G | 08:01:01G | 07:02:01G | 07:01:01G | 1,450,000 | 313 | ABA, 3TC, DTG | 16,279.3 | |
| 212 | CRF47 | 01:01:01G | 02:01:01G | 44:02:01G | 57:01:01G | 05:01:01G | 06:02:01G | 925,000 | NA | TDF, FTC, DTG | 18,229.7 | |
| 301 | B | 02:01:01G | 02:01:01G | 27:05:02G | 44:02:01G | 01:02:01G | 05:01:01G | 16,281 | 800 | TDF, FTC, DTG | 67,360.0 | |
| 303 | CRF02 | 25:01:01G | 68:01:02G | 18:01:01G | 44:02:01G | 05:01:01G | 07:01:01G | 2,274 | 930 | TDF, FTC, DTG | NA | |
| 304 | B | 02:01:01G | 02:01:01G | 40:01:01G | 51:01:01G | 03:04:01G | 15:02:01G | 317,431 | NA | TDF, FTC, DTG | 33,443.4 | |
| 308 | CRF01 | 02:01:01G | 02:01:01G | 49:01:01G | 55:01:01G | 03:03:01G | 07:01:01G | 4,180,000 | NA | TDF, FTC, DTG | 26,916.3 | |
| 402 | B | 01:01:01G | 23:01:01G | 14:02:01G | 45:01:01G | 06:02:01G | 08:02:01G | 18,100 | 950 | TDF, FTC, RAL | 1,001.0 | |
| 408 | B | 11:02:01G | 24:07:01G | 07:05:01G | 15:02:01G | 07:02:01G | 08:01:01G | 197,934 | 203 | TDF, FTC, DTG | 21,575.1 | |
| 411 | B | 01:01:01G | 29:02:01G | 52:01:01G | 57:01:01G | 04:01:01G | 06:02:01G | 762 | 1,098 | TDF, FTC, DTG | 40.5 | |
| 706 | B | 02:07:01G | 11:01:01G | 46:01:01G | 46:01:01G | 01:02:01G | 01:02:01G | 59,000 | 377 | ABA, 3TC, DTG | NA | |
| 709 | B | 01:01:01G | 02:01:01G | 15:01:01G | 49:01:01G | 03:04:01G | 07:01:01G | 41,000 | 531 | TAF, FTC, BIC | 1,522.7 | |
ART, antiretroviral therapy; CRF, circulating recombinant form; HLA, human leukocyte antigen; NA, not available; RMD, romidepsin.