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. 2023 May 3;25(6):289. doi: 10.3892/etm.2023.11988

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Copyright: © Xu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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IL-37 improves oxidative stress in diabetic ApoE-/- mice. Diabetic ApoE-/- mice were divided into two groups: i) STZ/HD group: The mice were fed with high-fat feed for 12 weeks and received the same amount of saline intraperitoneally; and ii) IL-37 group: The mice were fed with high-fat feed for 12 weeks and received IL-37 intraperitoneally (1 µg/week). (A and B) Western blotting was used to analyze the level of GPX4 and NRF2 in mice aortic lysate. (C) Serum IL-1β level in different groups. (D) Serum IL-18 level in different groups. (E) Serum MDA level in different groups. (F) Serum SOD level in different groups. (G) Serum GSH level in different groups. ^***P<0.001 vs. STZ/HD group. Each dot represents a biological repetition. STZ, streptozotocin; GPX4, glutathione peroxidase 4; NRF2, nuclear factor erythroid 2-related factor 2; MDA, malondialdehyde; SOD, superoxide dismutase; GSH, reduced glutathione.