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. 2023 May 3;14:1085610. doi: 10.3389/fimmu.2023.1085610

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Copyright © 2023 Forte, Pellegrino, Trabanelli, Tonetti, Ricci, Cenerenti, Comai, Tazzari, Lazzarotto, Buratta, Urbanelli, Narimanfar, Alabed, Mecucci, La Manna, Emiliani, Jandus, Ranieri, Cavo, Catani and Palandri

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IL-5 (A) and IL-10 (B) secretion by short-term expanded ILC2 isolated from HC stimulated with cytokines (IL-6, IL-8 and IP-10) alone or in the presence of either HC-EPs or Co-19-EPs. HC-EPs inhibited IL-5 (P<0.05) and IL-10 (P<0.01) production. (C–E) Expression of the activation markers CD38, CD69 and NKG2D in total ILC2 (C) and in cKit^low (D) and cKit^high (E) ILC2 (4-6 different donors were analyzed for each marker). *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.