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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: J Med Virol. 2023 Mar;95(3):e28673. doi: 10.1002/jmv.28673

Figure 2.

Figure 2.

Distinct binding profiles to RBD variants. (A) Epitope binning of 17B10 mAb with competitive mAbs (17A7, 2G5, 3A6 or 20B5) for RBD binding. Spike-specific rabbit polyclonal Ab (Rab) was used as control. (B-F) ELISA binding to different RBD variants: (B) original RBD; (C) Alpha RBD; D) Beta RBD; (E) Gamma RBD; (F) Delta RBD. OD at 450 nm (mean± SD, n= 4 replicates per mAb dilution) were plotted by nonlinear regression curve fit (Specific binding with Hill slope) with individual Kd values shown.