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. 2023 May 17;11:82. doi: 10.1186/s40478-023-01578-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Accelerated senescence enhances aberrant intracellular Aβ accumulation in 5xFAD mice. a Immunostaining analysis of Aβ42 (Aβ42 antibody, clone H31L21, red) in the subiculum from 1.5-month-old 5xFAD and G3Terc^−/− 5xFAD mice. Representative photomicrographs are shown. Quantitative analysis of intracellular Aβ42 was performed by counting cells displaying intracellular Aβ42 staining (arrows). Scale bar: 100 μm. ***P < 0.001 (two-tailed Student’s t-test, n = 5–7 mice/group). b Immunostaining analysis of Aβ42 and Aβ42-containing plaques (Aβ42 antibody, clone H31L21, red; Thioflavin T dye, green, colocalization indicated by arrows) in the subiculum from 2-month-old 5xFAD and G3Terc^−/− 5xFAD mice. Representative photomicrographs are shown. Scale bar: 100 μm. c Immunostaining analysis of Aβ42 (Aβ42 antibody, clone H31L21, red) in the cortical layer V region from 2-month-old 5xFAD and G3Terc^−/− 5xFAD mice. Representative photomicrographs are shown. Quantitative analysis of intracellular Aβ42 was performed by counting cells displaying intracellular Aβ42 staining (arrows). Scale bar: 200 μm. Non-significant (two-tailed Student’s t-test, n = 3–5 mice/group). All data are presented as the mean ± SEM