Fig. 4.

Accelerated senescence reduces Aβ plaque load in 5-month-old 5xFAD mice. Immunostaining analysis of Aβ42-containing plaques (Aβ42 antibody, clone H31L21, red; Thioflavin T dye, green) in the hippocampus (a) and cortical (b) regions from 5-month-old 5xFAD and G3Terc^−/− 5xFAD mice. Representative photomicrographs are shown. Quantitative analysis of Aβ deposition was performed by counting double-positive dots (arrows). Scale bar: 1000 μm. *P < 0.05 (two-tailed Student’s t-test, n = 6–7 mice/group). All data are presented as the mean ± SEM