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(A) Chemical formula of polyethylene glycol (PEG); (B) chemical structure of an exemplary branched PEG lipid, distearoylphosphatidylethanolamine-mPEG2,n (DSPE-mPEG2,n); (C) PEG and mPEG terminal groups; (D) mushroom versus brush PEG chain configurations depending on PEG density; and (E) exemplary structures of the widely used PEG–lipids in LNP formulations according to the CAS Content Collection.
