Table 1.
Dose BCP | Drug of Abuse | Behavioral Test | Result | CB2R Blockade | Specie | Refs. | |
Pharmacological | Genetic | ||||||
25, 50, and 100 mg/kg | Ethanol | Two-bottle choice | ↓ (50, 100) | x (50) | No | Mice | Al Mansouri et al. 2014 [26] |
CPP | ↓ (50) | x (50) | No | ||||
Loss of righting reflex | ↑ (50) | x (50) | No | ||||
30, 100, 178, and 300 mg/kg | Ethanol | Loss of righting reflex | ↑ (300) | No | No | Mice | Oppong-Damoah et al. 2019 [37] |
3, 10, 25, 50, and 100 mg/kg | Nicotine | Self-administration | ↓ (10, 25, 50) | x (25) | x (25) = (50) |
Mice and rat | He et al. 2020 [38] |
Seeking during extinction | ↓ (25, 50) | No | No | Mice | |||
Food self-administration | ↓ (50) | No | = (50) | Mice | |||
Electrical brain-stimulation | ↓ (50, 100) | No | No | Rat | |||
Optical brain-stimulation | ↓ (50, 100) | No | No | Mice | |||
Open field | - | No | No | Mice and rat | |||
Rotarod | ↓ (100) | No | No | Mice | |||
25, 50, and100mg/kg | Cocaine | Self-administration | ↓ (50, 100) | = (100) | No | Rat | Galaj et al. 2020 [33] |
↓ (100) | No | = (100) | Mice | ||||
Reinstatement | ↓ (25, 50) | No | No | Rat | |||
BCP self-administration | - | No | No | Rat | |||
CPP | ↓ (50, 100) | No | No | Rat | |||
Food self-administration | - | No | No | Rat | |||
Electrical brain-stimulation | - | No | No | Rat | |||
Optical brain-stimulation | ↓ (50, 100) | No | No | Mice | |||
Cocaine-induced hyperlocomotion | - | No | No | Rat | |||
10, 25, 50, and 100 mg/kg | Methamphetamine | Self-administration | ↓ (25, 50, 100) | x (50, 100) | No | Rat | He et al. 2021 [39] |
↓ (25, 50, 100) | No | x (25, 50) | Mice | ||||
Reinstatement | ↓ (25, 50) | No | No | Rat | |||
Cue-induced methamphetamine seeking |
↓ (50, 100) | No | No | Rat | |||
Electrical brain-stimulation | ↓ (50, 100) | No | No | Rat | |||
Methamphetamine-enhanced dopamine in NaC |
↓ (50) | No | No | Rat | |||
Open-field | - | No | No | Rat |
Note: ↓: BCP reduced the behavioral measure. ↑: BCP increased the behavioral measure. -: BCP did not have an effect. x: CB2R blockade impared BCP effect. =: same effect in WT and CB2KO or AM630. no: not measured. Number in parenthesis: dose of BCP with significant effect.