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. 2023 Feb 1;21(2):213–218. doi: 10.2174/1570159X20666220927115811

Table 1.

Summary of the main results found in the reviewed papers.

Dose BCP Drug of Abuse Behavioral Test Result CB2R Blockade Specie Refs.
Pharmacological Genetic
25, 50, and 100 mg/kg Ethanol Two-bottle choice ↓ (50, 100) x (50) No Mice Al Mansouri
et al. 2014
[26]
CPP ↓ (50) x (50) No
Loss of righting reflex ↑ (50) x (50) No
30, 100, 178, and 300 mg/kg Ethanol Loss of righting reflex ↑ (300) No No Mice Oppong-Damoah et al. 2019 [37]
3, 10, 25, 50, and 100 mg/kg Nicotine Self-administration ↓ (10, 25, 50) x (25) x (25)
= (50)
Mice and rat He et al. 2020
[38]
Seeking during extinction ↓ (25, 50) No No Mice
Food self-administration ↓ (50) No = (50) Mice
Electrical brain-stimulation ↓ (50, 100) No No Rat
Optical brain-stimulation ↓ (50, 100) No No Mice
Open field - No No Mice and rat
Rotarod ↓ (100) No No Mice
25, 50, and100mg/kg Cocaine Self-administration ↓ (50, 100) = (100) No Rat Galaj et al. 2020
[33]
↓ (100) No = (100) Mice
Reinstatement ↓ (25, 50) No No Rat
BCP self-administration - No No Rat
CPP ↓ (50, 100) No No Rat
Food self-administration - No No Rat
Electrical brain-stimulation - No No Rat
Optical brain-stimulation ↓ (50, 100) No No Mice
Cocaine-induced hyperlocomotion - No No Rat
10, 25, 50, and 100 mg/kg Methamphetamine Self-administration ↓ (25, 50, 100) x (50, 100) No Rat He et al. 2021
[39]
↓ (25, 50, 100) No x (25, 50) Mice
Reinstatement ↓ (25, 50) No No Rat
Cue-induced methamphetamine
seeking
↓ (50, 100) No No Rat
Electrical brain-stimulation ↓ (50, 100) No No Rat
Methamphetamine-enhanced
dopamine in NaC
↓ (50) No No Rat
Open-field - No No Rat

Note: ↓: BCP reduced the behavioral measure. ↑: BCP increased the behavioral measure. -: BCP did not have an effect. x: CB2R blockade impared BCP effect. =: same effect in WT and CB2KO or AM630. no: not measured. Number in parenthesis: dose of BCP with significant effect.