TABLE 2.
Susceptibility testing of recombinant E. coli strains
| Strain | MIC (μg/mL) for:a |
||||||
|---|---|---|---|---|---|---|---|
| IPM | I-R | MEM | MVB | CAZ | CZA | FDC | |
| E. coli TOP10+IMI-1 | >32 | 0.25 | 4–8 | ≤0.03 | 2 | 0.25 | 0.06 |
| E. coli TOP10+SME-1 | >32 | 1 | 32 | ≤0.03 | 4 | 0.25 | 0.06 |
| E. coli TOP10+NmcA | >32 | 1 | 16–32 | ≤0.03 | 4 | 0.25 | 0.06 |
| E. coli TOP10+FRI-1 | 4 | 0.25 | 0.5 | ≤0.03 | 2 | 0.25 | 0.06 |
| E. coli TOP10 | ≤0.125 | ≤0.125 | ≤0.03 | ≤0.03 | 0.25 | 0.25 | 0.06 |
a
MIC values were determined using the broth microdilution method. IPM, imipenem; I-R, imipenem/relebactam; MEM, meropenem; MVB, meropenem-vaborbactam; CAZ, ceftazidime; CZA, ceftazidime-avibactam; FDC, cefiderocol.