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IC50s of different β-lactamase inhibitors against the different carbapenemases tested
| Enzyme | IC50 (μM [mean ± SD]) for:a |
||
|---|---|---|---|
| Avibactam | Vaborbactam | Relebactam | |
| NmcA | 5.37 ± 0.3 | 4.8 ± 0.3 | 9.7 ± 1.2 |
| SME-1 | 1.8 ± 0.5 | 2.2 ± 0.4 | 5.9 ± 1.1 |
| IMI-1 | 1.9 ± 0.4 | 2.4 ± 0.5 | 6.3 ± 0.5 |
| FRI-1 | 1.4 ± 0.2 | 7.8 ± 0.2 | 16.5 ± 1.5 |
The IC50 represents the concentration of a drug that is required for 50% inhibition of the enzymatic activity.
