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. Author manuscript; available in PMC: 2023 May 17.
Published in final edited form as: Science. 2022 Nov 10;378(6620):627–634. doi: 10.1126/science.abq2844

Figure 4. Shape and Sequence Recognition of a DNA Target.

Figure 4.

(A). Secondary structure of the DNA target. (B). Interactions of the structured DNA with holoRNP. (C). Protein contacts with DNA helical stem. (D). Fit of the DNA groove against the protein palm linker. (E). DNA and D1 backbone interactions. (F). EBS-IBS base pairing interactions. (G). A stabilizing A-minor tertiary interaction. (H). Interactions between protein and single stranded DNA. (I-J). Intermolecular stacking interactions between DNA and (I) RNA nucleotides and (J) protein residues.