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. 2023 Apr 27;15(4):578–591. doi: 10.4240/wjgs.v15.i4.578

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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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Application prospects and challenges of tumor budding in gastric cancer. Tumor budding (TB) could potentially be considered relevant in the selection of patients for neoadjuvant therapy, management of early gastric cancer (GC) following endoscopic resection, therapy response prediction, and decision-making after radical gastrectomy. However, before its routine clinical application, several challenges need to be overcome: Standardization of the definition and assessment of peritumoral and intratumoral TB in GC according to subtypes. This figure was created with BioRender.com. GC: Gastric cancer; TB: Tumor budding.