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Schematic of mechanism of MK2 dependent nuclear translocation of caspase-3. MK2 associates with caspase-3 and translocates to the nucleus in the execution of apoptosis. Interfering with MK2’s NLS signaling prevents nuclear translocation and apoptosis. MK2, mitogen-activated protein kinase-activated protein kinase 2; NLS, nuclear localization sequence; NES, nuclear export sequence. [Image created with BioRender.com and published with permission.]
