Table 1.
Pressure-volume loop analysis summary
| Parameter | Control | PH | P Value |
|---|---|---|---|
| n | 10 | 14 | |
| Heart rate | 125.5 (22.7) | 162.4 (24.9) | 1.2E-03 |
| End-systolic pressure | 45.3 (8.7) | 118.3 (25.2) | 1.3E-08 |
| End-diastolic pressure | 11.1 (9.5) | 18.5 (8.3) | 0.11 NS |
| End-systolic volume | 24.8 (9.8) | 36.1 (19.8) | 0.11 NS |
| End-diastolic volume | 61.8 (13.6) | 73.7 (23.6) | 0.16 NS |
| Stroke volume | 37.0 (8.9) | 37.6 (7.6) | 0.85 NS |
| Cardiac output | 4.6 (1.7) | 6.0 (1.4) | 0.034 |
| dP/dtmax | 958 (421) | 2,002 (600) | 1.0E-04 |
| dP/dtmin | −697 (135) | −1,878 (426) | 2.4E-08 |
| Tau (Weiss) | 26.5 (18.0) | 26.5 (5.6) | 0.99 NS |
| Ejection fraction | 60.5 (11.5) | 53.8 (14.7) | 0.24 NS |
| Stroke work | 1,533 (447) | 3,454 (977) | 8.3E-06 |
| End-arterial elastance | 1.33 (0.35) | 3.42 (0.92) | 7.3E-07 |
Values are means (SD); n, number of animals. Parameters were obtained from analysis of pressure-volume relationships in control vs. calves with pulmonary hypertension (PH) as described in materials and methods. dP/dtmax and dP/dtmin, first derivative of left ventricular pressure increase and decline, respectively; NS, not significant.