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. 2021 Dec 28;1(3):20210023. doi: 10.1002/EXP.20210023

FIGURE 5.

FIGURE 5

Representative examples of US‐controlled non‐covalent bond scission for drug activation. (A) The PAPT loaded with neomycin B releases their cargo through US‐induced stretching and bond scission. Reproduced with permission.[ 23 ] Copyright 2021, Springer Nature. (B) Au NPs, DADA, and Van were assembled into Nanoparticle‐Nanoparticle systems to activate the antibacterial properties of Van. Reproduced with permission.[ 23 ] Copyright 2021, Springer Nature. (C) Mechanochemical release of non‐covalently bound drugs from polymer‐grafted supramolecular cages. Reproduced with permission.[ 129 ] Copyright 2021, John Wiley & Sons. (D) US‐induced unfolding of GFP modified by supercharged polypeptide. Reproduced with permission.[ 131 ] Copyright 2020, John Wiley & Sons. (E) US induces reversible NP disaggregation leading to thrombin release for catalysis. Reproduced with permission.[ 132 ] Copyright 2021, John Wiley & Sons. (F) US‐regulated dehybridization of metallo‐base paired DNA structures. Reproduced with permission.[ 133 ] Copyright 2021, Royal Society of Chemistry