FIGURE 11.

MSCs‐loaded detachable hybrid microneedle device for wound healing. (A) Design and working mechanism of d‐HMND (scale bar: 200 µm). (B) Histologic images of wound bed treated by each method on days 7 and 14 (scale bar:1 mm). G1: injury group, G2: MSCs injection group, G3: d‐HMND without MSCs group, G4: d‐HMND with MSCs group. (C) Re‐epithelialization and (D) MET length after 2 weeks. ^* p < 0.05 and ^** p < 0.01 compared with injury group. ^# p < 0.05 and ^## p < 0.01 compared with MSCs injection group; ^† p < 0.05 and ^†† p < 0.01 compared with d‐HMND without MSCs group. Reproduced with permission.^{[ 127 ]} Copyright 2020, Wiley‐VCH