FIGURE 13.

CeNZs‐loaded microneedles for scavenging ROS in AGA treatment. (A) Fabrication of CeMNs. DSPE‐mPEG₂₀₀₀ is used to transform hydrophobic CeNZs to hydrophilic CeNZs. (B) Working mechanisms of CeMNs to promote hair regrowth. (C) Evaluation of Ce‐MNst hair regeneration effect. (i) SEM images of regenerated hair at day 28 postdepilation (scale bar: 10 µm). (ii) Diameter of regenerated hair at day 28 postdepilation. (iii) Expression of Ki67 (red) and DAPI (blue) after 10 days (scale bar: 20 µm). (iv) Quantitative analysis of Ki67 positive cells at day 10 postdepilation. (v) H&E staining of the treated skin at day 10 postdepilation (scale bar: 100 µm). (vi) Hair cycle score calculations at day 10 postdepilation. ns: p > 0.05, ^* p < 0.05, ^*** p < 0.001. Reproduced with permission.^{[ 143 ]} Copyright 2021, American Chemical Society