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. 2023 Apr 5;3(2):20220115. doi: 10.1002/EXP.20220115

FIGURE 5.

FIGURE 5

Examples of mitochondria‐targeting nanomaterials that manipulate and respond to glucose oxidase. (A) Scheme of the preparation of IR780@PLGA‐GOx nanoplatform for mitochondrial targeted therapy (phototherapy combined with enzyme (GOx)‐induced starvation therapy). (B,C) Intracellular uptake of different nanoparticles with various incubation times and the corresponding flow cytometry analysis results and confocal laser scanning microscopy (CLSM) results to verify the colocalization within mitochondria. Reproduced with permission.[ 85 ] Copyright 2020, RSC Publishing Group. (D,E) The fabrication and mitochondrial‐targeted synergistic therapy (sonodynamic therapy (SDT)/starvation) of shell‐core nanostructured of IHG@P. Reproduced with permission.[ 86 ] Copyright 2020, RSC Publishing Group.