TABLE 1.

Overview of some strategies with mitochondria‐targeting reactive oxygen species (ROS) modulation functions for cancer therapy

ROS modulation Strategy	Cancer therapy strategy	Mitochondria‐targeting unit	Advantage	Ref
Redox homeostasis intervention strategy (RHIS)	Glutathione (GSH) depletion and ROS generation	Triphenylphosphonium (TPP)	Mitochondrial oxidative stress amplifier	[59]
	Chemodynamic therapy (CDT), photodynamic therapy (PDT)	Ir (III) complexes	Magnetothermogenic nanozyme	[78]
	CDT, GSH depletion, and chemotherapy (CT)	TPP‐PEG2K‐LND	pH‐responsive nanoprodrug	[79]
Energy metabolism regulation strategy (EMRS)	Photothermal therapy (PTT), PDT, glucose oxidase (GOx)‐induced starvation	IR780 dye	Deep tumor penetration	[85]
	Sonodynamic therapy (SDT), GOx‐induced starvation	IR780 dye	Deep tumor penetration	[86]
Combination therapy	CT, PTT	IR780 dye	Mitochondria‐responsive drug release	[87]
	Radiation therapy (RT)	TPP	Nanoradiosensitizer to enhance RT effect	[88]
	RT, radiodynamic therapy (RDT)	Cationic Ru‐based photosensitizers (DBB‐Ru)	Cationic nMOFs for mitochondria targeting	[89]
	PTT, PDT	IR780	PFOB‐based nanoliposomes act as the “Nano‐RBCs”	[90]
	SDT, gas therapy	IR780	Reverse immunosuppression	[91]
	PTT, PDT	DPP2+	New strategy to design mitochondria‐targeting photosensitizers	[92 ]
	PDT	TPP	Near‐infrared (NIR) light‐activated PDT nanoplatform	[93]
	Photochemotherapy	Cationic Ru2+ complex	Near infrared‐assisted Fenton reaction	[94]
	PDT, GOx‐induced starvation	TPP	Self‐supply of O2 and H2O2 to enhance PDT effect	[95]