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. 2022 May 23;2(5):20210145. doi: 10.1002/EXP.20210145

FIGURE 3.

FIGURE 3

Eradication effect of dynamic covalent polymeric antimicrobials for vancomycin‐resistant staphylococcal infection in vivo. (A) Workflow for Staphylococcus aureus Xen 36 infection, treatment, and bio‐optical imaging in mice. (B) Time series of bioluminescence images for S. aureus Xen36‐infected mice after treatment with PBS, PM@Van, PM@Cur, and PM@Van@Cur. (C) Relative bioluminescence intensity and (D) relative bioluminescent area arising from the infection site as a function of time after different treatments. Bioluminescence intensity of day 0 was set at 100%. Error bars represent SD values over six mice per group. p‐Values were calculated by one‐way ANOVA. *, ** indicate p < 0.05, p < 0.01 different from all other treatments. (E) Micrographs of H&E and Gram‐stained tissues of infected mice after different treatments. The untreated healthy mice were used as healthy control. Yellow arrows indicate the presence of inflammatory cells. Black arrows indicate the presence of S. aureus