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. 2023 Jan 5;3(1):20220045. doi: 10.1002/EXP.20220045

FIGURE 3.

FIGURE 3

Biomimetic macrophage membrane‐coating nanotechnology for the treatment of atherosclerosis. (A) Schematic diagram of fabrication of the macrophage membrane‐coated NPs (MM‐NPs). (B) TEM images of NPs (left) and MM‐NPs (right). Fluorescence imaging (C) and quantitative analysis (D) of aorta tissues from atherosclerotic mice harvested after injection of different formulations with the same dosage of Cy7.5 at 6 h. Cy7.5 was used to prepare Cy7.5‐loaded NPs (Cy7.5‐NPs), MM‐Cy7.5‐NPs, and Cy7.5‐NPs/MAs. Scale bar, 15 mm. (E) Images of Oil Red O‐stained aorta tissues (red region) in atherosclerotic mice after AT, AT‐NPs, MM‐AT‐NPs, and AT‐NPs/MAs treatments. Scale bars: 5 mm. (F) Quantitative analysis of plaque area relative to total aorta tissue area. Reproduced with permission.[ 51 ] Copyright 2020, Springer Nature.